Patients who respond to IT report periodic exacerbation of their symptoms as an apparent direct response to Benicar and pulsed antibiotics. This phenomenon is known as the Jarisch-Herxheimer Reaction and is often referred to informally as herx or herxing.
Herxing is believed to occur when injured or dead bacteria release their endotoxins into the blood and tissues faster than the body can comfortably handle it. This provokes a sudden and exaggerated inflammatory response....When the intraphagocytic bacteria are killed by the immune system, the cells they lived in also die (apoptosis). As the immune system tries to clear up this cellular debris, it releases a host of inflammatory molecules which, along with the toxins released by the bacteria as they die, cause a rise in symptoms in the area in which the bacteria are being killed."
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